Re: Možné těhotenství a antidepresiva

FDA pregnancy risk categories (SafeFefus):

Cipralex : C
Studies on animals show adverse effect and toxicity on fetus. No adequate and well controlled studies done on pregnant women. Drugs should be given only if the potential benefit outweighs the potential risk to the fetus.

The risk category will be D if taken in the second half of pregnancy (per Briggs"" Drugs in Pregnancy and Lactation).


Lamictal : C

Studies on animals show adverse effect and toxicity on fetus. No adequate and well controlled studies done on pregnant women. Drugs should be given only if the potential benefit outweighs the potential risk to the fetus.

Not teratogenic in animals but may cause intrauterine growth retardation, fetal or neonatal death, delayed ossification. Crosses human placenta.
No well controlled human data but suggested possible association with congenital anomalies in first trimester exposure including: neural tube defects, craniofacial, limb, cardiovascular, pulmonary, bone and digital defects.
Reported adverse neonatal effects of lamotrigine exposure in utero including: respiratory depression, growth retardation, septicemia, volvulus of ileum and NTD (neural tube defects).

Breast Feeding : Excreted into milk. No human data but not recommended during breast feeding.

Diazepam : D

Positive evidence of human fetal risk exists.
Potential benefits may warrant use of the drug in pregnant women despite potential risks (e.g. life threatening situations or serious illness).

Fetal Risk

Teratogenic in animals causing cleft palate, delayed neurobehavioral development and carcinogenic producing post-natal malignancies (Liver tumors) at high doses. Crosses human placenta. Possible association between diazepam and oral clefts, inguinal hernia, spina bifida, digital and limb defects in 1st trimester exposure.

No well controlled human data but benzodiazepines in general were suggested to be teratogenic producing multiple congenital malformations: craniofacial, renal defects, microcephaly, inguinal hernia, cryptorchidism, mental and psychomotor retardation with cortical dysplasia and heterotopias in the white matter of the brain, growth retardation and sudden infant death syndrome (SIDS).
Diazepam used for long period in pregnancy or at high doses causes neonatal withdrawal and floppy infant syndrome. causes loss of fetal heart beat to beat variability, decreased fetal movement and neonatal hypothermia.

Breast Feeding

Excreted into milk. Causes sedation and loss of weight in nursing infants so not recommended during lactation.